Nine of these studies are summarized in Table 119-1. Although data quality varied, Cyclo 3 Fort significantly reduced CVI symptoms compared with placebo. The review included information on 10,246 subjects. 1 A meta-analysis evaluated 20 placebo-controlled, double-blind studies and 5 randomized trials against a comparator drug along with 6 single-arm studies without a placebo. Both animal and clinical studies support its effectiveness in CVI, and the German Commission E approved butcher’s broom as an adjunct treatment for this condition. There are no studies indicating whether butcher’s broom alone would achieve the same results.īutcher’s broom is most commonly used to alleviate the symptoms of CVI, including ankle edema, itching, tension, and cramping of the legs. (sweet clover) in some topical preparations. All discussions of butcher’s broom trials in the following therefore include the possibility that it was not butcher’s broom by itself that was active.īutcher’s broom is also paired with Melilotus spp. However, other studies indicated that the combination may have a synergistic effect. Butcher’s broom has action independent of the other compounds in the formula, and some studies indicated that butcher’s broom used alone may have a stronger effect. These formulas combine butcher’s broom with trimethylhesperidin chalcone (a flavonoid precursor) and ascorbic acid. Instead, most of the clinical studies investigated a proprietary combination formula known as Cyclo 3 Fort by Pierre Fabre Medicament of Paris, France, or Phlebodril by Pierre Fabre Pharma GmbH of Freiburg, Germany. There are few clinical studies on the effect of butcher’s broom alone.
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